MOTS-c is a mitochondrial-derived peptide that has attracted attention in research focused on metabolism, exercise performance, and cellular energy regulation. Researchers are interested in MOTS-c because it may help influence how the body uses glucose, responds to physical stress, and adapts to metabolic demands.
Scientific Information
- Full Name: Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c)
- Structure: MOTS-c is a short mitochondrial-derived peptide encoded within mitochondrial DNA, making it different from many conventional peptide hormones produced from nuclear DNA.
Research & Potential Benefits
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Metabolic Regulation:
Research suggests MOTS-c may help regulate glucose metabolism and improve metabolic flexibility in skeletal muscle and other tissues. (Reference 1, 2) -
Exercise Performance Research:
Studies have examined MOTS-c for its potential role in exercise adaptation and improved physical performance. (Reference 2, 3) -
Healthy Aging Research:
MOTS-c has also been studied for its possible role in healthspan and age-related metabolic resilience. (Reference 1, 4) -
Cellular Energy Signaling:
Because it is mitochondria-derived, MOTS-c is a key area of interest in research on cellular energy signaling and stress responses. (Reference 1, 4)
References
- Lee, C. et al. “MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.” Free Radical Biology and Medicine.
- Reynolds, J.C. et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications.
- Hyatt, J.P.K. et al. “MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose.” Frontiers in Physiology.
- Zheng, Y. et al. “MOTS-c: A promising mitochondrial-derived peptide for metabolic disorders and aging-related diseases.” Frontiers in Endocrinology.
Disclaimer
For Research Use Only. Not for human consumption.